WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Cell cycle       ID:04110
C=124; O=13; E=0.26; R=50.24; rawP=6.55e-19; adjP=6.55e-18
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000093009 NA CDC45 cell division cycle 45 homolog (S. cerevisiae) 8318 ENSG00000093009
2  ENSG00000166851 NA PLK1 polo-like kinase 1 5347 ENSG00000166851
3  ENSG00000164109 NA MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 4085 ENSG00000164109
4  ENSG00000117399 NA CDC20 cell division cycle 20 homolog (S. cerevisiae) 991 ENSG00000117399
5  ENSG00000164611 NA PTTG1 pituitary tumor-transforming 1 9232 ENSG00000164611
6  ENSG00000101412 NA E2F1 E2F transcription factor 1 1869 ENSG00000101412
7  ENSG00000169679 NA BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 699 ENSG00000169679
8  ENSG00000149554 NA CHEK1 checkpoint kinase 1 1111 ENSG00000149554
9  ENSG00000094804 NA CDC6 cell division cycle 6 homolog (S. cerevisiae) 990 ENSG00000094804
10  ENSG00000127564 NA PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 9088 ENSG00000127564
11  ENSG00000134057 NA CCNB1 cyclin B1 891 ENSG00000134057
12  ENSG00000157456 NA CCNB2 cyclin B2 9133 ENSG00000157456
13  ENSG00000170312 NA CDK1 cyclin-dependent kinase 1 983 ENSG00000170312


Database:KEGG pathway       Name:Oocyte meiosis       ID:04114
C=112; O=9; E=0.23; R=38.51; rawP=2.29e-12; adjP=1.14e-11
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166851 NA PLK1 polo-like kinase 1 5347 ENSG00000166851
2  ENSG00000169679 NA BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 699 ENSG00000169679
3  ENSG00000127564 NA PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 9088 ENSG00000127564
4  ENSG00000134057 NA CCNB1 cyclin B1 891 ENSG00000134057
5  ENSG00000157456 NA CCNB2 cyclin B2 9133 ENSG00000157456
6  ENSG00000170312 NA CDK1 cyclin-dependent kinase 1 983 ENSG00000170312
7  ENSG00000164109 NA MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 4085 ENSG00000164109
8  ENSG00000117399 NA CDC20 cell division cycle 20 homolog (S. cerevisiae) 991 ENSG00000117399
9  ENSG00000164611 NA PTTG1 pituitary tumor-transforming 1 9232 ENSG00000164611


Database:KEGG pathway       Name:Progesterone-mediated oocyte maturation       ID:04914
C=86; O=7; E=0.18; R=39.00; rawP=6.39e-10; adjP=2.13e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000166851 NA PLK1 polo-like kinase 1 5347 ENSG00000166851
2  ENSG00000169679 NA BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 699 ENSG00000169679
3  ENSG00000127564 NA PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 9088 ENSG00000127564
4  ENSG00000134057 NA CCNB1 cyclin B1 891 ENSG00000134057
5  ENSG00000157456 NA CCNB2 cyclin B2 9133 ENSG00000157456
6  ENSG00000170312 NA CDK1 cyclin-dependent kinase 1 983 ENSG00000170312
7  ENSG00000164109 NA MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 4085 ENSG00000164109


Database:KEGG pathway       Name:p53 signaling pathway       ID:04115
C=68; O=5; E=0.14; R=35.23; rawP=3.32e-07; adjP=8.30e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171848 NA RRM2 ribonucleotide reductase M2 6241 ENSG00000171848
2  ENSG00000149554 NA CHEK1 checkpoint kinase 1 1111 ENSG00000149554
3  ENSG00000134057 NA CCNB1 cyclin B1 891 ENSG00000134057
4  ENSG00000157456 NA CCNB2 cyclin B2 9133 ENSG00000157456
5  ENSG00000170312 NA CDK1 cyclin-dependent kinase 1 983 ENSG00000170312


Database:KEGG pathway       Name:Pyrimidine metabolism       ID:00240
C=99; O=4; E=0.21; R=19.36; rawP=5.74e-05; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000176890 NA TYMS thymidylate synthetase 7298 ENSG00000176890
2  ENSG00000171848 NA RRM2 ribonucleotide reductase M2 6241 ENSG00000171848
3  ENSG00000167900 NA TK1 thymidine kinase 1, soluble 7083 ENSG00000167900
4  ENSG00000100479 NA POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 5427 ENSG00000100479


Database:KEGG pathway       Name:Pancreatic cancer       ID:05212
C=70; O=2; E=0.15; R=13.69; rawP=0.0095; adjP=0.0158
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000051180 NA RAD51 RAD51 homolog (S. cerevisiae) 5888 ENSG00000051180
2  ENSG00000101412 NA E2F1 E2F transcription factor 1 1869 ENSG00000101412


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=3; E=0.68; R=4.41; rawP=0.0310; adjP=0.0408
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000089685 NA BIRC5 baculoviral IAP repeat containing 5 332 ENSG00000089685
2  ENSG00000051180 NA RAD51 RAD51 homolog (S. cerevisiae) 5888 ENSG00000051180
3  ENSG00000101412 NA E2F1 E2F transcription factor 1 1869 ENSG00000101412


Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=2; E=0.28; R=7.10; rawP=0.0326; adjP=0.0408
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000175063 NA UBE2C ubiquitin-conjugating enzyme E2C 11065 ENSG00000175063
2  ENSG00000117399 NA CDC20 cell division cycle 20 homolog (S. cerevisiae) 991 ENSG00000117399


Database:KEGG pathway       Name:Purine metabolism       ID:00230
C=162; O=2; E=0.34; R=5.92; rawP=0.0453; adjP=0.0503
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171848 NA RRM2 ribonucleotide reductase M2 6241 ENSG00000171848
2  ENSG00000100479 NA POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 5427 ENSG00000100479


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=5; E=2.36; R=2.12; rawP=0.0878; adjP=0.0878
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000176890 NA TYMS thymidylate synthetase 7298 ENSG00000176890
2  ENSG00000171848 NA RRM2 ribonucleotide reductase M2 6241 ENSG00000171848
3  ENSG00000167900 NA TK1 thymidine kinase 1, soluble 7083 ENSG00000167900
4  ENSG00000100479 NA POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 5427 ENSG00000100479
5  ENSG00000079462 NA PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 5050 ENSG00000079462




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).